EPAS1 regulates proliferation of erythroblasts in chronic mountain sickness
نویسندگان
چکیده
منابع مشابه
Chronic Mountain Sickness
Introduction Chronic mountain sickness (CMS) affects people who are native or long time residents of high altitude. It is characterized by an excessive erythrocytosis for the altitude of residence, severe hypoxemia and in many cases, particularly in severe CMS, high altitude pulmonary hypertension (HAPH). CMS usually begins insidiously in adult life associated probably to aging; the clinical pi...
متن کاملChronic mountain sickness.
I read with great interest the article by White et al,’ which appeared in the July 1991 issue ofChest. The authors raised several important points concerning the utility of chest radiographs in adults admitted for exacerbations of bronchial asthma, I feel, however, that several aspects oftheir study must be addressed. First ofall, the study is relatively small (n =58) and uncontrolled, and invo...
متن کاملPathology of chronic mountain sickness.
Arias-Stella, J., Kriiger, H., and Recavarren, S. (1973). Thorax, 28, 701-708. Pathology of chronic mountain sickness. Pathological data on chronic mountain sickness are scarce due to the fact that the disease is ameliorated or cured by descent to a low altitude. In this report we describe a case of chronic mountain sickness occurring in a woman of 48 years at Cerro de Pasco (4,300 m above sea ...
متن کاملThe genetic basis of chronic mountain sickness.
Chronic mountain sickness (CMS) is a disease that affects many high-altitude dwellers, particularly in the Andean Mountains in South America. The hallmark symptom of CMS is polycythemia, which causes increased risk of pulmonary hypertension and stroke (among other symptoms). A prevailing hypothesis in high-altitude medicine is that CMS results from a population-specific "maladaptation" to the h...
متن کاملSNPs, linkage disequilibrium, and chronic mountain sickness in Tibetan Chinese
Chronic mountain sickness (CMS) is estimated at 1.2% in Tibetans living at the Qinghai-Tibetan Plateau. Eighteen single-nucleotide polymorphisms (SNPs) from nine nuclear genes that have an association with CMS in Tibetans have been analyzed by using pairwise linkage disequilibrium (LD). The SNPs included are the angiotensin-converting enzyme (rs4340), the angiotensinogen (rs699), and the angiot...
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ژورنال
عنوان ژورنال: Blood Cells, Molecules, and Diseases
سال: 2020
ISSN: 1079-9796
DOI: 10.1016/j.bcmd.2020.102446